Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | QDPR | P09417 | 2/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL158531 | 0.88 | QDPR (0.55) | LSSQDPRSLC18A3HDAC3HDAC4 | |
| SCHEMBL22452582 | 0.83 | CYP3A4 (0.43) | SLC18A3ALDH1A1GFERESR2MAPK1 | |
| SCHEMBL22453195 | 0.81 | SLC18A3 (0.44) | SLC18A3HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL14257946 | 0.81 | SLC18A3 (0.58) | LSSQDPRSLC18A3HDAC3HDAC4 | |
| SCHEMBL22452594 | 0.80 | ESR2 (0.50) | SLC18A3ALDH1A1GFERKDM4EMAPT | |
| SCHEMBL328439 | 0.79 | SLC18A3 (0.53) | LSSQDPRSLC18A3HDAC3HDAC4 | |
| SCHEMBL22744420 | 0.78 | LSS (0.44) | LSSQDPRSLC18A3ESR2HSP90AA1 | |
| SCHEMBL14320804 | 0.78 | SLC18A3 (0.46) | LSSQDPRSLC18A3HTR1DHTR1B | |
| SCHEMBL22453528 | 0.77 | ESR2 (0.40) | SLC18A3ALDH1A1GFERGAAESR2 | |
| SCHEMBL2056213 | 0.77 | HTR2A (0.52) | LSSQDPRALDH1A1KMT2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |