Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | IDE | P14735 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452572 | 0.88 | MAPT (0.45) | MAPTHTTNPSR1CYP2C9TDP1 | |
| SCHEMBL22453415 | 0.83 | SERPINE1 (0.53) | MAPTHSD17B10SERPINE1MEN1TP53 | |
| SCHEMBL22453101 | 0.80 | CYP19A1 (0.38) | MAPTHTTNPSR1CYP2C9MEN1 | |
| SCHEMBL22452561 | 0.80 | SERPINE1 (0.44) | SERPINE1ALDH1A1NPC1HIF1AEPAS1 | |
| SCHEMBL22452687 | 0.79 | EPHX2 (0.53) | SERPINE1CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL22453320 | 0.78 | NPC1 (0.41) | HSD17B10SERPINE1CYP2C9TDP1LMNA | |
| SCHEMBL22452684 | 0.77 | HIF1A (0.52) | MAPTHSD17B10SERPINE1HPGDALDH1A1 | |
| SCHEMBL22452974 | 0.77 | HIF1A (0.53) | SERPINE1NPC1HIF1AEPAS1 | |
| SCHEMBL22452686 | 0.76 | KDM5A (0.50) | SERPINE1NPC1HIF1AEPAS1 | |
| SCHEMBL22452486 | 0.75 | HIF1A (0.50) | MAPTSERPINE1CYP2C9TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |