Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452785 | 0.88 | MAPT (0.48) | MAPTNPSR1HTTHIF1AHPGD | |
| SCHEMBL22453545 | 0.86 | HPGD (0.52) | MAPTNPSR1HIF1AHPGDMAPK1 | |
| SCHEMBL22453142 | 0.81 | EPHX2 (0.40) | HIF1AHPGDMAPK1RECQLSMN1; SMN2 | |
| SCHEMBL22452573 | 0.81 | EPHX2 (0.57) | MAPTHIF1ACYP2C9EPHX2 | |
| SCHEMBL22453409 | 0.80 | HIF1A (0.49) | MAPTHIF1AHPGDMAPK1RECQL | |
| SCHEMBL22453411 | 0.78 | SYK (0.39) | MAPTNPSR1HTTHIF1AHPGD | |
| SCHEMBL22453417 | 0.77 | CYP11B1 (0.48) | MAPTNPSR1HTTHIF1AGRM2 | |
| SCHEMBL22453416 | 0.77 | HIF1A (0.42) | MAPTHIF1AHPGDMAPK1RECQL | |
| SCHEMBL22453101 | 0.76 | CYP19A1 (0.38) | MAPTNPSR1HTTCYP2C9CYP1A2 | |
| SCHEMBL22453415 | 0.73 | SERPINE1 (0.53) | MAPTHIF1AHPGDMAPK1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |