Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.36 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553063 | 0.92 | LRRK2 (0.52) | LRRK2ACP1GSK3BPGRAR | |
| SCHEMBL20552322 | 0.82 | LRRK2 (0.52) | LRRK2ACP1GSK3BPGRAR | |
| SCHEMBL20552334 | 0.79 | TRPV1 (0.44) | LRRK2ACP1MEN1KMT2AAKR1C3 | |
| SCHEMBL22452720 | 0.79 | MEN1 (0.60) | MEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL22452887 | 0.79 | AKR1C3 (0.48) | ACP1MAPK14MEN1KMT2AAKR1C3 | |
| SCHEMBL22452871 | 0.78 | AKR1C3 (0.47) | ACP1MAPK14MEN1KMT2AAKR1C3 | |
| SCHEMBL22452872 | 0.78 | AKR1C3 (0.47) | ACP1MAPK14MEN1KMT2AAKR1C3 | |
| SCHEMBL20552937 | 0.77 | MEN1 (0.43) | LRRK2ACP1MEN1KMT2AAKR1C3 | |
| SCHEMBL20552788 | 0.75 | LRRK2 (0.49) | LRRK2ARMEN1KMT2AAKR1C3 | |
| SCHEMBL11163318 | 0.74 | AHR (0.46) | GSK3BPTGIRMEN1KMT2AKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |