SCHEMBL22452887

SCHEMBL22452887

COC(=O)c1cc(OC)ccc1Nc1ccc(N(C)c2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 7/20 0.48
AKR1C2 P52895 7/20 0.48
TUBB4A P04350 2/20 0.48
TUBB P07437 2/20 0.48
TUBA3C P0DPH7 2/20 0.48
TUBA1B P68363 2/20 0.48
TUBA4A P68366 2/20 0.48
TUBB4B P68371 2/20 0.48
TUBB3 Q13509 2/20 0.48
TUBB2A Q13885 2/20 0.48
TUBB8 Q3ZCM7 2/20 0.48
TUBA3E Q6PEY2 2/20 0.48
TUBA1A Q71U36 2/20 0.48
TUBA1C Q9BQE3 2/20 0.48
TUBB6 Q9BUF5 2/20 0.48
TUBB2B Q9BVA1 2/20 0.48
TUBB1 Q9H4B7 2/20 0.48
MEN1 O00255 2/20 0.48
LMNA P02545 2/20 0.48
KMT2A Q03164 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22452720 0.91 MEN1 (0.60) AKR1C3AKR1C2MEN1LMNAKMT2A
SCHEMBL22452871 0.90 AKR1C3 (0.47) AKR1C3AKR1C2TUBB4ATUBBTUBA3C
SCHEMBL22452872 0.90 AKR1C3 (0.47) AKR1C3AKR1C2MEN1LMNAKMT2A
SCHEMBL22453590 0.90 MEN1 (0.49) AKR1C3AKR1C2TUBB4ATUBBTUBA3C
SCHEMBL22452878 0.89 AKR1C3 (0.47) AKR1C3AKR1C2TUBB4ATUBBTUBA3C
SCHEMBL22453439 0.88 TUBB4A (0.46) AKR1C3AKR1C2TUBB4ATUBBTUBA3C
SCHEMBL22453599 0.88 TUBB4A (0.46) AKR1C3AKR1C2TUBB4ATUBBTUBA3C
SCHEMBL22453399 0.88 TUBB4A (0.46) AKR1C3AKR1C2TUBB4ATUBBTUBA3C
SCHEMBL22452960 0.88 DHODH (0.45) AKR1C3AKR1C2TUBB4ATUBBTUBA3C
SCHEMBL22452916 0.88 TUBB4A (0.46) AKR1C3AKR1C2TUBB4ATUBBTUBA3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020190774-A1 NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS THE GENERAL HOSPITAL CORPORATION (US) 2020-09-24 WO disclosed