Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 8/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | MDH1 | P40925 | 1/20 | 0.38 |
| ▸ | MDH2 | P40926 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452627 | 0.94 | CNR2 (0.51) | CNR2NPC1HIF1AEPAS1MDH1 | |
| SCHEMBL22453558 | 0.90 | CNR2 (0.47) | CNR2HIF1AEPAS1MDH1MDH2 | |
| SCHEMBL22453241 | 0.90 | NPC1 (0.44) | CNR2NPC1HIF1AEPAS1CASP2 | |
| SCHEMBL22452655 | 0.90 | CNR2 (0.46) | CNR2NPC1HIF1AEPAS1MDH1 | |
| SCHEMBL22452628 | 0.89 | CNR2 (0.47) | CNR2NPC1HIF1AEPAS1MDH1 | |
| SCHEMBL22452574 | 0.89 | CNR2 (0.41) | CNR2NPC1HIF1AEPAS1MDH1 | |
| SCHEMBL22453560 | 0.86 | CNR2 (0.44) | CNR2HIF1AEPAS1CASP2MAPT | |
| SCHEMBL22452666 | 0.85 | CNR2 (0.43) | CNR2HIF1AEPAS1MDH1MDH2 | |
| SCHEMBL22452674 | 0.84 | CNR2 (0.42) | CNR2HIF1AEPAS1MDH1MDH2 | |
| SCHEMBL22453242 | 0.82 | HIF1A (0.43) | CNR2NPC1HIF1AEPAS1CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |