Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 10/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MDH1 | P40925 | 2/20 | 0.38 |
| ▸ | MDH2 | P40926 | 2/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452941 | 0.89 | HIF1A (0.40) | HIF1ANPC1EPAS1CNR2MDH1 | |
| SCHEMBL22453267 | 0.89 | SERPINE1 (0.42) | HIF1ANPC1EPAS1MAPTSERPINE1 | |
| SCHEMBL22453117 | 0.87 | CNR2 (0.53) | HIF1ANPC1EPAS1CNR2MAPT | |
| SCHEMBL22453555 | 0.83 | HIF1A (0.44) | HIF1ANPC1EPAS1MDH1MDH2 | |
| SCHEMBL22452942 | 0.82 | HIF1A (0.41) | HIF1ANPC1EPAS1CNR2MDH1 | |
| SCHEMBL22453494 | 0.81 | CNR2 (0.56) | HIF1AEPAS1CNR2MDH1MDH2 | |
| SCHEMBL22452580 | 0.81 | CNR2 (0.52) | HIF1AEPAS1CNR2MDH1MDH2 | |
| SCHEMBL22453720 | 0.81 | KMT2A (0.40) | HIF1ANPC1EPAS1MDH1MDH2 | |
| SCHEMBL22453525 | 0.81 | MAPT (0.50) | HIF1ANPC1EPAS1CNR2MDH1 | |
| SCHEMBL22453269 | 0.80 | SERPINE1 (0.42) | HIF1ANPC1EPAS1SERPINE1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |