Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.40 |
| ▸ | MDH1 | P40925 | 1/20 | 0.40 |
| ▸ | MDH2 | P40926 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452790 | 0.92 | SERPINE1 (0.51) | MAPTALOX15SIRT2NPC1TSHR | |
| SCHEMBL22453680 | 0.92 | SERPINE1 (0.53) | MAPTALOX15NPC1TSHRHSD17B10 | |
| SCHEMBL22453774 | 0.90 | LMNA (0.47) | MAPTALOX15HSD17B10KMT2AMEN1 | |
| SCHEMBL22453775 | 0.90 | LMNA (0.49) | MAPTALOX15TSHRHSD17B10KMT2A | |
| SCHEMBL22452617 | 0.90 | TAS2R14 (0.44) | MAPTALOX15EPHX2PTGS2TSHR | |
| SCHEMBL22453205 | 0.89 | MAPT (0.46) | MAPTALOX15EPHX2HIF1AEPAS1 | |
| SCHEMBL22452486 | 0.88 | HIF1A (0.50) | MAPTEPHX2PTGS2NPC1HIF1A | |
| SCHEMBL22452503 | 0.88 | MAPT (0.58) | MAPTALOX15EPHX2SIRT2NPC1 | |
| SCHEMBL22453322 | 0.88 | POLB (0.44) | MAPTEPHX2NPC1HIF1ALMNA | |
| SCHEMBL22452762 | 0.87 | SIRT2 (0.46) | EPHX2SIRT2NPC1HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |