Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452498 | 0.89 | HIF1A (0.60) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL31555348 | 0.89 | HIF1A (0.60) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22453658 | 0.89 | MAPT (0.49) | HIF1AEPAS1EPHX2NPC1AURKA | |
| SCHEMBL22452724 | 0.87 | HIF1A (0.46) | HIF1AEPAS1EPHX2MAPK8AKR1C3 | |
| SCHEMBL22453247 | 0.84 | EPHX2 (0.65) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22452502 | 0.83 | HIF1A (0.54) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22453806 | 0.82 | HIF1A (0.51) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22452810 | 0.81 | HIF1A (0.53) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22453497 | 0.81 | SERPINE1 (0.57) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22452527 | 0.81 | SERPINE1 (0.57) | HIF1AEPAS1EPHX2FABP4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |