Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.60 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452498 | 1.00 | HIF1A (0.60) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22452502 | 0.94 | HIF1A (0.54) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22453247 | 0.93 | EPHX2 (0.65) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22452485 | 0.91 | EPHX2 (0.52) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22452850 | 0.91 | HIF1A (0.52) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22453497 | 0.90 | SERPINE1 (0.57) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22452810 | 0.90 | HIF1A (0.53) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22452527 | 0.90 | SERPINE1 (0.57) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22453511 | 0.89 | HIF1A (0.54) | HIF1AEPAS1EPHX2FABP4NPC1 | |
| SCHEMBL22452488 | 0.88 | SERPINE1 (0.64) | HIF1AEPAS1EPHX2NPC1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122194-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION | 2025-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122194-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | TEAD1, TEAD2, TEAD3 | HIF1A 668/4885EPAS1 285/4885EPHX2 3663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.