Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.55 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452488 | 0.94 | SERPINE1 (0.64) | SERPINE1HIF1AEPAS1PGREPHX2 | |
| SCHEMBL22453497 | 0.93 | SERPINE1 (0.57) | SERPINE1HIF1AEPAS1PGREPHX2 | |
| SCHEMBL22452527 | 0.93 | SERPINE1 (0.57) | SERPINE1HIF1AEPAS1PGREPHX2 | |
| SCHEMBL22452760 | 0.89 | HIF1A (0.67) | SERPINE1HIF1AEPAS1DHODHNPC1 | |
| SCHEMBL22453766 | 0.88 | HPGD (0.56) | SERPINE1HIF1AEPAS1PGREPHX2 | |
| SCHEMBL22453291 | 0.88 | SERPINE1 (0.52) | SERPINE1HIF1AEPAS1PGREPHX2 | |
| SCHEMBL22452754 | 0.85 | SERPINE1 (0.58) | SERPINE1HIF1AEPAS1PGREPHX2 | |
| SCHEMBL22452690 | 0.85 | SIRT2 (0.57) | SERPINE1HIF1AEPAS1PGREPHX2 | |
| SCHEMBL22453292 | 0.85 | SERPINE1 (0.58) | SERPINE1HIF1AEPAS1PGREPHX2 | |
| SCHEMBL22452498 | 0.82 | HIF1A (0.60) | SERPINE1HIF1AEPAS1EPHX2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |