Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453784 | 0.96 | SERPINE1 (0.56) | SERPINE1HIF1AEPAS1PPARGPPARA | |
| SCHEMBL22453629 | 0.90 | SERPINE1 (0.48) | SERPINE1HIF1AEPAS1PPARGPPARA | |
| SCHEMBL22452715 | 0.89 | SERPINE1 (0.64) | SERPINE1HIF1AEPAS1PPARGPPARA | |
| SCHEMBL22452488 | 0.88 | SERPINE1 (0.64) | SERPINE1HIF1AEPAS1DHODHMEN1 | |
| SCHEMBL22452789 | 0.86 | SERPINE1 (0.61) | SERPINE1HIF1AEPAS1PPARGPPARA | |
| SCHEMBL22453220 | 0.86 | SERPINE1 (0.46) | SERPINE1HIF1AEPAS1MEN1KMT2A | |
| SCHEMBL22452527 | 0.85 | SERPINE1 (0.57) | SERPINE1HIF1AEPAS1DHODHMEN1 | |
| SCHEMBL22453497 | 0.85 | SERPINE1 (0.57) | SERPINE1HIF1AEPAS1DHODHMEN1 | |
| SCHEMBL22453626 | 0.85 | SERPINE1 (0.65) | SERPINE1HIF1AEPAS1DHODHMEN1 | |
| SCHEMBL22452754 | 0.81 | SERPINE1 (0.58) | SERPINE1HIF1AEPAS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |