Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452726 | 0.91 | DHODH (0.45) | DHODHRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22453641 | 0.89 | DHODH (0.55) | DHODHRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22452713 | 0.89 | DHODH (0.43) | DHODHRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22453248 | 0.88 | DHODH (0.49) | DHODHRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22452725 | 0.88 | MEN1 (0.46) | MEN1KMT2AALDH1A1LMNACCR2 | |
| SCHEMBL22453640 | 0.86 | DHODH (0.57) | DHODHRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22452983 | 0.86 | MEN1 (0.48) | MEN1KMT2AALDH1A1LMNACCR2 | |
| SCHEMBL22452804 | 0.84 | SERPINE1 (0.57) | DHODHRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22453002 | 0.84 | DHODH (0.50) | DHODHRAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22453313 | 0.83 | DHODH (0.48) | DHODHRAB9AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |