Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22445906 | 0.80 | ALDH1A1 (0.46) | MAPTGAASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL22445905 | 0.80 | ALDH1A1 (0.46) | MAPTGAASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL22454037 | 0.76 | SMN1; SMN2 (0.44) | KDM4EMAPTGAASMN1; SMN2LMNA | |
| SCHEMBL22445798 | 0.72 | CYP3A4 (0.52) | KDM4EMAPTGAASMN1; SMN2LMNA | |
| SCHEMBL22445802 | 0.71 | SMN1; SMN2 (0.46) | KDM4EMAPTGAASMN1; SMN2LMNA | |
| SCHEMBL7362801 | 0.66 | POLB (0.60) | KDM4EMAPTGAASMN1; SMN2LMNA | |
| SCHEMBL9523494 | 0.65 | ALDH1A1 (0.53) | KDM4EMAPTGAASMN1; SMN2LMNA | |
| SCHEMBL1296287 | 0.65 | CYP3A4 (0.56) | KDM4EMAPTGAASMN1; SMN2LMNA | |
| SCHEMBL3277897 | 0.64 | SMN1; SMN2 (0.50) | KDM4EMAPTGAASMN1; SMN2LMNA | |
| SCHEMBL22453926 | 0.64 | SMN1; SMN2 (0.52) | KDM4EMAPTGAASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |