Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 5/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22445883 | 0.74 | JAK2 (0.44) | JAK2JAK1LRRK2KDM4EALDH1A1 | |
| SCHEMBL22445882 | 0.74 | LRRK2 (0.45) | JAK2JAK1LRRK2KDM4EALDH1A1 | |
| SCHEMBL22889932 | 0.72 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL18167981 | 0.72 | JAK2 (0.52) | JAK2JAK1LRRK2ULK1 | |
| SCHEMBL22445920 | 0.71 | RAB9A (0.48) | JAK2JAK1LRRK2KDM4EALDH1A1 | |
| SCHEMBL22445968 | 0.71 | RAB9A (0.47) | JAK2JAK1LRRK2KDM4EALDH1A1 | |
| SCHEMBL12286618 | 0.71 | JAK2 (0.63) | JAK2JAK1LRRK2ULK1 | |
| SCHEMBL14014041 | 0.71 | ITK (0.57) | JAK2JAK1KDM4EALDH1A1 | |
| SCHEMBL22445904 | 0.70 | LRRK2 (0.43) | JAK2JAK1LRRK2KDM4EALDH1A1 | |
| SCHEMBL16847274 | 0.69 | MAPK1 (0.44) | JAK2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020191261-A1 | INDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |