Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.55 |
| ▸ | INSR | P06213 | 8/20 | 0.54 |
| ▸ | IGF1R | P08069 | 8/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.54 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22460082 | 0.82 | PTK2 (0.51) | EGFRINSRIGF1RALKAURKA | |
| SCHEMBL22460083 | 0.81 | ALK (0.51) | EGFRINSRIGF1RALKMAP4K1 | |
| SCHEMBL24565166 | 0.80 | EGFR (0.55) | EGFRALKROS1 | |
| SCHEMBL22460081 | 0.77 | ALK (0.49) | EGFRINSRIGF1RALKMAP4K1 | |
| SCHEMBL29833019 | 0.75 | EGFR (0.64) | EGFRINSRIGF1RALKMAP4K1 | |
| SCHEMBL28685651 | 0.75 | EGFR (0.61) | EGFRINSRIGF1RALKMAP4K1 | |
| SCHEMBL15442490 | 0.75 | INSR (0.78) | EGFRINSRIGF1RALKMAP4K1 | |
| SCHEMBL22460085 | 0.75 | ALK (0.50) | EGFRINSRIGF1RALKMAP4K1 | |
| SCHEMBL29833000 | 0.74 | EGFR (0.74) | EGFRINSRIGF1RALKMAP4K1 | |
| SCHEMBL22460072 | 0.74 | INSR (0.52) | EGFRINSRIGF1RALKMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020188467-A1 | CONDENSED TRICYCLIC COMPOUND USED AS KINASE INHIBITOR | 杭州英创医药科技有限公司 | 2020-09-24 | — | — | WO | disclosed |