Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28682081 | 0.88 | KDM4E (0.47) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL22460280 | 0.82 | KDM4E (0.41) | KDM4EALDH1A1GAARAB9AKMT2A | |
| SCHEMBL11296276 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL30923499 | 0.79 | CYP11B1 (0.53) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL29237778 | 0.79 | CYP11B1 (0.53) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL30923498 | 0.79 | CYP11B1 (0.53) | KDM4EALDH1A1GLAGAAHSD17B10 | |
| SCHEMBL29279278 | 0.78 | KMT2A (0.55) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL30336285 | 0.78 | KMT2A (0.55) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL16277802 | 0.78 | CYP46A1 (0.66) | KDM4EALDH1A1GLAGAAHTT | |
| SCHEMBL19817203 | 0.77 | RAB9A (0.52) | KDM4EALDH1A1HTTRAB9AALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200299260-A1 | Fumarate Salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, Methods of Preparation, and Uses Thereof | HELSINN HEALTHCARE SA (CH) | 2020-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299260-A1 | Fumarate Salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, Methods of Preparation, and Uses Thereof | MECP2, DOT1L, MC4R | KDM4E 325/4885ALDH1A1 2081/4885GLA 2719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.