Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.66 |
| ▸ | JAK1 | P23458 | 12/20 | 0.66 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22462090 | 0.90 | JAK2 (0.65) | JAK2JAK1 | |
| SCHEMBL22462089 | 0.90 | JAK1 (0.66) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL14563734 | 0.84 | JAK2 (0.52) | JAK2JAK1 | |
| SCHEMBL27182358 | 0.84 | JAK2 (0.51) | JAK2JAK1 | |
| SCHEMBL14563845 | 0.83 | JAK2 (0.50) | JAK2JAK1 | |
| SCHEMBL14563676 | 0.82 | JAK2 (0.69) | JAK2JAK1 | |
| SCHEMBL2397928 | 0.80 | JAK2 (1.00) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL3377118 | 0.79 | JAK1 (0.53) | JAK2JAK1JAK3TYK2 | |
| SCHEMBL17387434 | 0.79 | JAK2 (0.65) | JAK2JAK1 | |
| SCHEMBL14563474 | 0.79 | JAK2 (0.66) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3715347-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2020-09-30 | — | — | EP | disclosed |