SCHEMBL22469745

SCHEMBL22469745

Brc1cccc(COCc2ccccc2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.62
IDO1 P14902 2/20 0.62
AGXT P21549 2/20 0.62
MAOB P27338 8/20 0.61
HCAR2 Q8TDS4 1/20 0.50
TAAR1 Q96RJ0 1/20 0.48
GLA P06280 1/20 0.48
FFAR1 O14842 1/20 0.46
FFAR4 Q5NUL3 1/20 0.46
MAOA P21397 1/20 0.46
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45
ESR1 P03372 1/20 0.45
NR3C1 P04150 1/20 0.45
PGR P06401 1/20 0.45
NR3C2 P08235 1/20 0.45
AR P10275 1/20 0.45
THRA P10827 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31568444 1.00 TSHR (0.62) TSHRIDO1AGXTMAOBHCAR2
SCHEMBL1767187 0.94 IDO1 (0.69) TSHRIDO1AGXTMAOBHCAR2
Bromobenzene SCHEMBL17868575 0.87 TSHR (0.75) TSHRIDO1AGXTMAOB
SCHEMBL2407393 0.86 MAOB (0.57) TSHRIDO1AGXTMAOBFFAR1
SCHEMBL9347048 0.85 IDO1 (0.64) IDO1AGXTMAOBHCAR2TAAR1
SCHEMBL5238199 0.85 MAOB (0.54) TSHRIDO1AGXTMAOBHCAR2
SCHEMBL29007243 0.84 TSHR (0.79) TSHRIDO1AGXTMAOB
SCHEMBL6291712 0.83 IDO1 (0.62) IDO1AGXTMAOBHCAR2TAAR1
SCHEMBL12526332 0.82 MAOB (0.62) IDO1AGXTMAOBFFAR1FFAR4
SCHEMBL11019425 0.82 IDO1 (0.60) IDO1AGXTMAOBHCAR2TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3946304-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2022-02-09 EP disclosed
WO-2020198537-A1 MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS ESCIENT PHARMACEUTICALS, INC. (US) 2020-10-01 WO disclosed