Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 10/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768971 | 0.93 | DGAT1 (0.53) | DGAT1HSP90AB1GBA1EPHX2EP300 | |
| SCHEMBL24276657 | 0.93 | DGAT1 (0.53) | DGAT1HSP90AB1GBA1EPHX2EP300 | |
| SCHEMBL18768970 | 0.88 | HSP90AB1 (0.51) | DGAT1HSP90AB1EPHX2EP300HDAC3 | |
| SCHEMBL22473625 | 0.87 | DGAT1 (0.59) | DGAT1HSP90AB1GBA1EPHX2EP300 | |
| SCHEMBL22473784 | 0.87 | DGAT1 (0.59) | DGAT1GBA1HDAC3HDAC4HDAC1 | |
| SCHEMBL22473667 | 0.87 | DGAT1 (0.49) | DGAT1HSP90AB1GBA1EPHX2MMP2 | |
| SCHEMBL22473778 | 0.86 | DGAT1 (0.60) | DGAT1HSP90AB1MMP2MMP9MMP8 | |
| SCHEMBL21118027 | 0.85 | DGAT1 (0.52) | DGAT1GBA1EPHX2 | |
| SCHEMBL21118075 | 0.85 | DGAT1 (0.52) | DGAT1GBA1EPHX2 | |
| SCHEMBL22473764 | 0.85 | DGAT1 (0.57) | DGAT1HSP90AB1GBA1EPHX2EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | BRAF, RAF1, ARAF | DGAT1 1679/4885HSP90AB1 695/4885GBA1 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.