Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 12/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22473810 | 0.99 | DGAT1 (0.60) | DGAT1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22473655 | 0.92 | DGAT1 (0.52) | DGAT1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22473779 | 0.92 | DGAT1 (0.52) | DGAT1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22473623 | 0.91 | DGAT1 (0.52) | DGAT1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22473683 | 0.91 | DGAT1 (0.51) | DGAT1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22473815 | 0.90 | DGAT1 (0.52) | DGAT1MMP2MMP9MMP8MMP13 | |
| SCHEMBL22473625 | 0.88 | DGAT1 (0.59) | DGAT1MMP2MMP9MMP8MMP13 | |
| SCHEMBL22473784 | 0.88 | DGAT1 (0.59) | DGAT1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22473786 | 0.87 | DGAT1 (0.48) | DGAT1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22473778 | 0.87 | DGAT1 (0.60) | DGAT1MMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | BRAF, RAF1, ARAF | DGAT1 1679/4885HDAC3 2276/4885HDAC4 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.