Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22473814 | 0.88 | EPHX2 (0.47) | FOLH1EPHX2HDAC1 | |
| SCHEMBL22473681 | 0.88 | EPHX2 (0.47) | FOLH1EPHX2HDAC1 | |
| SCHEMBL22473749 | 0.87 | HDAC1 (0.47) | FOLH1EPHX2HDAC1DGAT1 | |
| SCHEMBL22473769 | 0.86 | EPHX2 (0.46) | FOLH1EPHX2HDAC1 | |
| SCHEMBL18161456 | 0.86 | FOLH1 (0.58) | FOLH1EPHX2HDAC1 | |
| SCHEMBL24675933 | 0.86 | EPHX2 (0.52) | FOLH1EPHX2HDAC1DGAT1 | |
| SCHEMBL22473665 | 0.86 | EPHX2 (0.46) | FOLH1EPHX2HDAC1 | |
| SCHEMBL22473676 | 0.86 | EPHX2 (0.46) | FOLH1EPHX2HDAC1 | |
| SCHEMBL22473679 | 0.86 | EPHX2 (0.46) | FOLH1EPHX2HDAC1 | |
| SCHEMBL22473767 | 0.85 | GBA1 (0.46) | FOLH1EPHX2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | ZAMBONI CHEM SOLUTIONS INC. (CA) | 2020-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10787443-B2 | RAF-degrading conjugate compounds | BRAF, RAF1, ARAF | FOLH1 350/4885EPHX2 557/4885HDAC1 1577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.