Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.47 |
| ▸ | GBA1 | P04062 | 6/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18769031 | 0.91 | EPHX2 (0.59) | EPHX2GBA1HDAC1L3MBTL1HRH4 | |
| SCHEMBL18768800 | 0.89 | EPHX2 (0.57) | EPHX2FOLH1GBA1HDAC1L3MBTL1 | |
| SCHEMBL20364737 | 0.88 | HRH4 (0.48) | EPHX2FOLH1GBA1HRH4HRH3 | |
| SCHEMBL14648773 | 0.88 | HRH4 (0.48) | EPHX2FOLH1GBA1HRH4HRH3 | |
| SCHEMBL19704892 | 0.88 | EPHX2 (0.52) | EPHX2FOLH1GBA1HDAC1L3MBTL1 | |
| SCHEMBL3435452 | 0.87 | HRH4 (0.47) | EPHX2FOLH1GBA1DGAT1HRH4 | |
| SCHEMBL22473750 | 0.86 | FOLH1 (0.48) | EPHX2FOLH1DGAT1HDAC1 | |
| SCHEMBL24675920 | 0.86 | EPHX2 (0.67) | EPHX2GBA1HRH4HRH3 | |
| SCHEMBL3434906 | 0.85 | HRH4 (0.48) | EPHX2FOLH1GBA1HRH4HRH3 | |
| SCHEMBL18160354 | 0.85 | HRH4 (0.48) | EPHX2FOLH1GBA1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |