Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15464127 | 0.82 | SMN1; SMN2 (0.52) | KMT2AMEN1SMN1; SMN2TSHRCRHBP | |
| SCHEMBL19050697 | 0.77 | KMT2A (0.51) | KMT2AMEN1MAPTCYP1A2CYP3A4 | |
| SCHEMBL11004175 | 0.75 | MEN1 (0.64) | KMT2AMEN1MAPTCYP1A2CYP3A4 | |
| SCHEMBL11902238 | 0.74 | L3MBTL1 (0.51) | KMT2AMEN1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL944514 | 0.73 | TDP1 (0.44) | KMT2AMEN1MAPTCYP1A2CYP3A4 | |
| SCHEMBL390986 | 0.71 | MAP2K1 (0.58) | — | |
| SCHEMBL7739956 | 0.71 | TDP1 (0.46) | KMT2AMEN1MAPTCYP3A4POLB | |
| SCHEMBL2481319 | 0.70 | TDP1 (0.54) | MAPTCYP1A2CYP3A4SMN1; SMN2TSHR | |
| SCHEMBL29902915 | 0.70 | TDP1 (0.54) | MAPTCYP1A2CYP3A4SMN1; SMN2TSHR | |
| SCHEMBL6392737 | 0.70 | MAPK1 (0.59) | KMT2AMEN1MAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2880028-B1 | ANTIDIABETIC TRICYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2020-09-30 | — | — | EP | disclosed |