Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.81 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15320847 | 0.94 | ALOX15 (0.88) | ALOX15PTGER4LMNABRD4MEN1 | |
| SCHEMBL15321088 | 0.92 | ALOX15 (0.84) | ALOX15PTGER4LMNABRD4MEN1 | |
| SCHEMBL15320804 | 0.91 | ALOX15 (0.83) | ALOX15PTGER4BRD4MEN1POLB | |
| SCHEMBL15320668 | 0.90 | ALOX15 (0.81) | ALOX15PTGER4BRD4MEN1POLB | |
| SCHEMBL15320822 | 0.90 | ALOX15 (0.81) | ALOX15PTGER4BRD4MEN1POLB | |
| SCHEMBL15320767 | 0.90 | ALOX15 (0.81) | ALOX15PTGER4BRD4MEN1POLB | |
| SCHEMBL15320680 | 0.90 | ALOX15 (1.00) | ALOX15PTGER4LMNACYP1A2BRD4 | |
| SCHEMBL15319696 | 0.89 | ALOX15 (0.80) | ALOX15PTGER4BRD4MEN1KMT2A | |
| SCHEMBL19239515 | 0.88 | ALOX15 (0.78) | ALOX15PTGER4BRD4MEN1POLB | |
| SCHEMBL15320283 | 0.88 | ALOX15 (0.81) | ALOX15PTGER4CYP3A4BRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3384908-B1 | MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS | UNIV COLUMBIA (US) | 2020-09-30 | — | — | EP | disclosed |