Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 5/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | MGMT | P16455 | 2/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18521191 | 0.88 | CCNE1 (0.67) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL20782336 | 0.85 | CDK1 (0.58) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL23247753 | 0.84 | PNP (0.56) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL29767910 | 0.84 | PNP (0.56) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL10643467 | 0.83 | BLM (0.56) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL5929994 | 0.83 | CCNE1 (0.47) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL12522765 | 0.80 | CDK1 (0.50) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL18521819 | 0.80 | CDK1 (0.44) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL1567264 | 0.79 | FGFR1 (0.58) | CCNE1CDK2CDK1CCNB1CYP2C19 | |
| SCHEMBL22300666 | 0.78 | CCNE1 (0.70) | CCNE1CDK2CDK1CCNB1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160476-B1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTION | JANSSEN BIOPHARMA INC (US) | 2020-09-30 | — | — | EP | disclosed |