Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 4/20 | 0.67 |
| ▸ | CDK2 | P24941 | 4/20 | 0.67 |
| ▸ | CDK1 | P06493 | 3/20 | 0.67 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22474871 | 0.88 | CCNE1 (0.51) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL20782336 | 0.88 | CDK1 (0.58) | CCNE1CDK2CDK1CCNB1ADORA2A | |
| SCHEMBL17364319 | 0.88 | CDK1 (0.67) | CCNE1CDK2CDK1CCNB1ADORA2A | |
| SCHEMBL5929994 | 0.83 | CCNE1 (0.47) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL18521819 | 0.83 | CDK1 (0.44) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL12522765 | 0.83 | CDK1 (0.50) | CCNE1CDK2CDK1CCNB1ADORA2A | |
| SCHEMBL23247753 | 0.81 | PNP (0.56) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL29767910 | 0.81 | PNP (0.56) | CCNE1CDK2CDK1CCNB1HSP90AA1 | |
| SCHEMBL8767031 | 0.80 | CCNE1 (1.00) | CCNE1CDK2CDK1CCNB1ADORA2A | |
| SCHEMBL10643467 | 0.80 | BLM (0.56) | CCNE1CDK2CDK1CCNB1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230201236-A1 | SPIROCYCLIC NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF HEPATITIS E | Janssen Pharmaceuticals, Inc. | 2023-06-29 | — | — | US | disclosed |
| US-11666594-B2 | Antibody-drug conjugates comprising a cyclic dinucleotide | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-06-06 | — | — | US | disclosed |
| US-20210206796-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2021-07-08 | — | — | US | disclosed |
| US-20210106607-A1 | ANTIBODY-DRUG CONJUGATES COMPRISING A CYCLIC DINUCLEOTIDE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-04-15 | — | — | US | disclosed |
| WO-2020117623-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2020-06-11 | — | — | WO | disclosed |
| US-20170044206-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210106607-A1 | ANTIBODY-DRUG CONJUGATES COMPRISING A CYCLIC DINUCLEOTIDE | STING1, TLR9, CGAS | CCNE1 4880/4885CDK2 4868/4885CDK1 4739/4885 |
| US-20210206796-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | STING1, CGAS, IFNAR1 | CCNE1 2444/4885CDK2 3858/4885CDK1 1534/4885 |
| US-11666594-B2 | Antibody-drug conjugates comprising a cyclic dinucleotide | STING1, TLR9, CGAS | CCNE1 4880/4885CDK2 4868/4885CDK1 4739/4885 |
| US-20170044206-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | STING1, CGAS, IFNAR1 | CCNE1 2421/4885CDK2 3890/4885CDK1 1642/4885 |
| US-20230201236-A1 | SPIROCYCLIC NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF HEPATITIS E | HAVCR2, NME2, SLC10A1 | CCNE1 574/4885CDK2 1374/4885CDK1 2652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.