Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 7/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADA | P00813 | 1/20 | 0.33 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | AHCY | P23526 | 1/20 | 0.32 |
| ▸ | HINT1 | P49773 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16374113 | 0.91 | ADORA2A (0.40) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B | |
| SCHEMBL18672103 | 0.91 | ADORA2A (0.40) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B | |
| SCHEMBL16368132 | 0.91 | ADORA2A (0.40) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B | |
| SCHEMBL19590324 | 0.87 | ADORA2A (0.35) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B | |
| SCHEMBL16647595 | 0.86 | ADORA2A (0.39) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B | |
| SCHEMBL20754490 | 0.85 | ADORA2A (0.40) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B | |
| SCHEMBL31228203 | 0.85 | ADORA2A (0.39) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B | |
| SCHEMBL31228544 | 0.85 | ADORA2A (0.39) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B | |
| SCHEMBL31228188 | 0.83 | ADORA2A (0.38) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B | |
| SCHEMBL31228206 | 0.83 | ADORA2A (0.38) | ADORA2ASLC29A1ADORA3ADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160476-B1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF FOR USE IN THE TREATMENT OF VIRAL INFECTION | JANSSEN BIOPHARMA INC (US) | 2020-09-30 | — | — | EP | disclosed |