Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 5/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.36 |
| ▸ | KDR | P35968 | 6/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PI4KA | P42356 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23127929 | 0.89 | CSF1R (0.53) | CSF1RMETATRMAPK1FGFR1 | |
| SCHEMBL21167637 | 0.87 | SYK (0.38) | SYKMETFGFR1FGFR3KDR | |
| SCHEMBL22475798 | 0.85 | CSF1R (0.40) | CSF1RSYKATRMAPK1FGFR1 | |
| SCHEMBL21167557 | 0.84 | CSF1R (0.42) | CSF1RSYKMETATRMAPK1 | |
| SCHEMBL21167558 | 0.79 | CSF1R (0.41) | CSF1RSYKMETATRFGFR1 | |
| SCHEMBL21167411 | 0.78 | CSF1R (0.41) | CSF1RSYKMETFGFR1FGFR3 | |
| SCHEMBL21167533 | 0.77 | MET (0.45) | CSF1RMETATRMAPK1PIK3CD | |
| SCHEMBL16882483 | 0.76 | MET (0.37) | SYKMETFGFR1FGFR3KDR | |
| SCHEMBL24591009 | 0.76 | PIK3CD (0.35) | CSF1RSYKMETMAPK1FGFR1 | |
| SCHEMBL12487424 | 0.75 | MET (0.57) | METPDE3BPDE3APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |