Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | APP | P05067 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12729862 | 0.79 | MCHR1 (0.39) | NPC1RAB9AAPPKDM4EALDH1A1 | |
| SCHEMBL798511 | 0.79 | MCHR1 (0.45) | NPC1RAB9AAPPKDM4EALDH1A1 | |
| SCHEMBL13961197 | 0.76 | NPC1 (0.55) | NPC1RAB9AAPPKDM4EALDH1A1 | |
| SCHEMBL23197729 | 0.75 | APP (0.38) | NPC1RAB9AAPPKDM4EALDH1A1 | |
| SCHEMBL22479214 | 0.75 | SMN1; SMN2 (0.35) | NPC1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL29136817 | 0.75 | MAP3K5 (0.38) | NPC1RAB9AAPPKDM4EALDH1A1 | |
| SCHEMBL29304400 | 0.75 | KDM4E (0.41) | NPC1RAB9AAPPKDM4EALDH1A1 | |
| SCHEMBL18389508 | 0.75 | MCHR1 (0.43) | NPC1RAB9AAPPKDM4EALDH1A1 | |
| SCHEMBL25045602 | 0.74 | APP (0.49) | NPC1RAB9AAPPKDM4EALDH1A1 | |
| SCHEMBL24737348 | 0.74 | KDM4E (0.40) | NPC1RAB9AAPPKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198435-A1 | SMALL MOLECULE DEGRADERS OF STAT3 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-10-01 | — | — | WO | disclosed |