Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 8/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24834491 | 0.78 | NPC1 (0.52) | MAP3K5TP53KDM4EAPPMEN1 | |
| SCHEMBL12729862 | 0.77 | MCHR1 (0.39) | TP53KDM4EAPPMCHR1MEN1 | |
| SCHEMBL798511 | 0.77 | MCHR1 (0.45) | TP53KDM4EAPPMCHR1MEN1 | |
| Hydrochloric Acid SCHEMBL28842904 | 0.77 | NPC1 (0.50) | MAP3K5CSNK1DCSNK1G2TP53KDM4E | |
| SCHEMBL14445622 | 0.75 | MAP3K5 (0.47) | MAP3K5ABL1MCHR1PIK3CA | |
| SCHEMBL22479121 | 0.75 | NPC1 (0.33) | TP53KDM4EAPPMCHR1MEN1 | |
| SCHEMBL28842738 | 0.75 | MAP3K5 (0.52) | MAP3K5CSNK1DCSNK1G2TP53KDM4E | |
| SCHEMBL28800311 | 0.75 | PIK3CG (0.55) | MAP3K5TP53KDM4EAPPMEN1 | |
| SCHEMBL24242318 | 0.75 | MAP3K5 (0.36) | MAP3K5CSNK1DCSNK1G2TP53KDM4E | |
| SCHEMBL26432426 | 0.75 | KDM4E (0.58) | MAP3K5TP53KDM4EAPPABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |