Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21238857 | 0.84 | KDM4E (0.79) | KDM4EALDH1A1MAPTGBA1POLB | |
| SCHEMBL8196129 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1MAPTGBA1POLB | |
| SCHEMBL8183946 | 0.75 | KDM4E (0.49) | KDM4EALDH1A1MAPTGBA1POLB | |
| SCHEMBL17739788 | 0.73 | KDM4E (0.77) | KDM4EALDH1A1MAPTGBA1POLB | |
| SCHEMBL1422926 | 0.72 | KDM4E (1.00) | KDM4EALDH1A1MAPTGBA1POLB | |
| SCHEMBL15760593 | 0.72 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPTGBA1POLB | |
| SCHEMBL9300782 | 0.70 | KDM4E (0.71) | KDM4EALDH1A1MAPTGBA1POLB | |
| SCHEMBL17732306 | 0.70 | KDM4E (0.71) | KDM4EALDH1A1MAPTGBA1POLB | |
| SCHEMBL2930949 | 0.70 | KDM4E (0.77) | KDM4EALDH1A1MAPTGBA1POLB | |
| SCHEMBL1006755 | 0.70 | KDM4E (0.70) | KDM4EALDH1A1MAPTGBA1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198379-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. (US) | 2020-10-01 | — | — | WO | disclosed |