SCHEMBL2248103

SCHEMBL2248103

O=C(Nc1ccc(O)c(-c2nc3ccccc3s2)c1)c1ccccc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 15/20 0.74
MEN1 O00255 8/20 0.74
KMT2A Q03164 8/20 0.74
KDM4E B2RXH2 4/20 0.74
RAB9A P51151 4/20 0.74
GAA P10253 2/20 0.72
LMNA P02545 1/20 0.72
RXFP1 Q9HBX9 5/20 0.71
POLB P06746 4/20 0.69
MMP2 P08253 1/20 0.68
MMP9 P14780 1/20 0.68
MMP8 P22894 1/20 0.68
MMP13 P45452 1/20 0.68
SMN1; SMN2 Q16637 5/20 0.68
NPC1 O15118 3/20 0.68
HPGD P15428 2/20 0.68
ALDH1A1 P00352 1/20 0.68
EGFR P00533 1/20 0.64
INSR P06213 1/20 0.64
IGF1R P08069 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12963182 0.92 MAPT (0.83) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12980262 0.91 MAPT (0.69) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL16602315 0.91 MAPT (0.72) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12963178 0.89 MAPT (0.66) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12963448 0.88 EGFR (0.70) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12980314 0.87 EGFR (0.84) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL2245625 0.87 MAPT (0.76) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12979901 0.86 MAPT (0.73) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL12645167 0.86 MAPT (0.68) MAPTMEN1KMT2AKDM4ERAB9A
SCHEMBL2246115 0.85 MAPT (1.00) MAPTMEN1KMT2AKDM4ERAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4707297-A Removable guidepath for automated guidance vehicles BELL & HOWELL COMPANY (US) 1987-11-17 US claimed
US-20150150852-A1 TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS SIGA TECHNOLOGIES, INC. (US) 2015-06-04 US disclosed
US-20150150852-A1 TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS SIGA TECHNOLOGIES, INC. (US) 2015-06-04 US disclosed
US-8993604-B2 Treatment and prevention of dengue virus infections SIGA TECHNOLOGIES, INC. (US) 2015-03-31 US disclosed
US-8993604-B2 Treatment and prevention of dengue virus infections SIGA TECHNOLOGIES, INC. (US) 2015-03-31 US disclosed
US-20120258079-A1 Treatment and Prevention of Dengue Virus Infections SIGA TECHNOLOGIES, INC. 2012-10-11 US disclosed
US-20120258079-A1 Treatment and Prevention of Dengue Virus Infections SIGA TECHNOLOGIES, INC. 2012-10-11 US disclosed
US-8283015-B2 Authenticatable articles and methods therefor SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-10-09 US disclosed
US-8283015-B2 Authenticatable articles and methods therefor SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-10-09 US disclosed
US-8283015-B2 Authenticatable articles and methods therefor SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2012-10-09 US disclosed
US-20080081210-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081210-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
US-20080081210-A1 AUTHENTICATABLE ARTICLES AND METHODS THEREFOR GENERAL ELECTRIC COMPANY (US) 2008-04-03 US disclosed
WO-2008039587-A1 AUTHENTICATABLE POLYMER ARTICLES COMPRISING BENZOXAZOLE AND BENZOTHIAZOLE AUTHENTICATION COMPOUNDS GENERAL ELECTRIC COMPANY (US) 2008-04-03 WO disclosed
EP-1162936-A4 BODY COATING COMPOSITION PYRAMID PRODUCTIONS INC (US) 2006-01-04 EP disclosed
US-6582684-B1 A fluorescent and/or phosphorescent coating composition, particularly useful as a body coating, hair coating, lipstick and particularly as a phosphorescent nail polish that has the capability of changing from transparent, or other color, in XSIGHT INTERNATIONAL 2003-06-24 US disclosed
EP-1162936-A1 BODY COATING COMPOSITION Pyramid Productions Inc. (US) 2001-12-19 EP disclosed
WO-2000056274-A1 BODY COATING COMPOSITION PYRAMID PRODUCTIONS, INC. (US) 2000-09-28 WO disclosed
US-5896297-A Robotube delivery system VALERINO SR FRED M (US) 1999-04-20 US disclosed
US-4707297-A Removable guidepath for automated guidance vehicles BELL & HOWELL COMPANY (US) 1987-11-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150150852-A1 TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS HAVCR2, TTPA, CHIA MAPT 118/4885MEN1 4028/4885KMT2A 1695/4885
US-20120258079-A1 Treatment and Prevention of Dengue Virus Infections HAVCR2, TTPA, CHIA MAPT 118/4885MEN1 4028/4885KMT2A 1695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.