Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12184825 | 0.85 | MTNR1A (0.39) | MTNR1AKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL5392965 | 0.80 | — | — | |
| SCHEMBL9893063 | 0.80 | BRD4 (0.43) | MTNR1AKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL13854076 | 0.78 | — | — | |
| SCHEMBL6707040 | 0.77 | EPHX1 (0.56) | MTNR1AKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL20695749 | 0.77 | — | — | |
| SCHEMBL8392768 | 0.77 | EPHX1 (0.52) | MTNR1AKDM4EMAPK1HIF1ATSHR | |
| SCHEMBL8392277 | 0.75 | EPHX1 (0.59) | KDM4EMAPK1HIF1ATSHREPHX1 | |
| SCHEMBL931424 | 0.75 | EPHX1 (0.59) | KDM4EMAPK1HIF1ATSHREPHX1 | |
| SCHEMBL21660832 | 0.73 | KDM4E (0.41) | MTNR1AKDM4EMAPK1HIF1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198583-A1 | BICYCLIC JAK INHIBITORS AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2020-10-01 | — | — | WO | disclosed |