Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | F13A1 | P00488 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24333752 | 0.81 | KMT2A (0.36) | MAPK1TSHRKMT2A | |
| SCHEMBL22482075 | 0.79 | KDM4E (0.46) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL18629003 | 0.74 | KDM4E (0.41) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL22482085 | 0.69 | KDM4E (0.40) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL24618588 | 0.69 | KDM4E (0.40) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL22482095 | 0.68 | OPRM1 (0.41) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL22482084 | 0.68 | KDM4E (0.54) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL22434968 | 0.67 | KDM4E (0.46) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL25608117 | 0.65 | KDM4E (0.44) | KDM4EMAPK1HIF1ATSHRALDH1A1 | |
| SCHEMBL25106399 | 0.65 | NPSR1 (0.41) | KDM4EMAPK1HIF1ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198583-A1 | BICYCLIC JAK INHIBITORS AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2020-10-01 | — | — | WO | disclosed |