Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22483020 | 0.83 | HDAC6 (0.77) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL22482884 | 0.81 | HDAC6 (0.55) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL22483024 | 0.69 | HDAC6 (0.81) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL22483006 | 0.69 | HDAC6 (1.00) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL22482769 | 0.69 | HDAC6 (1.00) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL22482992 | 0.69 | HDAC8 (0.57) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL22482773 | 0.68 | HDAC6 (1.00) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL22482911 | 0.68 | HDAC6 (0.71) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL29665752 | 0.67 | HDAC6 (0.57) | HDAC6HDAC8HDAC3HDAC2HDAC1 | |
| SCHEMBL22482996 | 0.67 | HDAC6 (0.69) | HDAC6HDAC8HDAC3HDAC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020194272-A1 | HALOGENATED PHENYLSULFONAMIDE HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS AND USES THEREOF AS SELECTIVE HDAC6 INHIBITORS | 2681603 ONTARIO INC. (CA) | 2020-10-01 | — | — | WO | disclosed |