Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24472780 | 0.76 | HDAC6 (0.60) | HDAC6HDAC3HDAC8HDAC2HDAC11 | |
| SCHEMBL22483007 | 0.76 | HDAC8 (0.79) | HDAC6HDAC3HDAC8HDAC2HDAC11 | |
| SCHEMBL24472873 | 0.69 | HDAC6 (0.60) | HDAC6HDAC3HDAC8HDAC2HDAC11 | |
| SCHEMBL22483019 | 0.67 | HDAC6 (0.79) | HDAC6HDAC3HDAC8HDAC2HDAC11 | |
| SCHEMBL21743362 | 0.67 | HDAC6 (0.53) | HDAC6HDAC3HDAC8HDAC2HDAC11 | |
| SCHEMBL22482985 | 0.67 | HDAC6 (0.56) | HDAC6HDAC3HDAC8HDAC11HDAC4 | |
| SCHEMBL20847641 | 0.67 | SLC6A2 (0.40) | — | |
| SCHEMBL22482986 | 0.65 | HDAC8 (1.00) | HDAC6HDAC3HDAC8HDAC2HDAC11 | |
| SCHEMBL30754590 | 0.65 | HDAC6 (0.50) | HDAC6HDAC3HDAC8HDAC2HDAC11 | |
| SCHEMBL27360991 | 0.65 | HDAC6 (0.50) | HDAC6HDAC3HDAC8HDAC2HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020194272-A1 | HALOGENATED PHENYLSULFONAMIDE HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS AND USES THEREOF AS SELECTIVE HDAC6 INHIBITORS | 2681603 ONTARIO INC. (CA) | 2020-10-01 | — | — | WO | disclosed |