Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22483039 | 0.90 | HDAC6 (0.47) | HDAC6HDAC8HDAC11HDAC3CA12 | |
| SCHEMBL22482999 | 0.89 | HDAC6 (0.48) | HDAC6HDAC8HDAC11HDAC3CA12 | |
| SCHEMBL22482763 | 0.79 | HDAC6 (0.81) | HDAC6HDAC8HDAC11HDAC3HDAC2 | |
| SCHEMBL24473203 | 0.79 | HDAC6 (0.58) | HDAC6HDAC8HDAC11HDAC3 | |
| SCHEMBL19167335 | 0.75 | GSTP1 (0.48) | LMNAALDH1A1 | |
| SCHEMBL24473205 | 0.74 | GSTP1 (0.42) | HDAC6HDAC8HDAC11HDAC3ALDH1A1 | |
| SCHEMBL22483031 | 0.72 | HDAC6 (0.62) | HDAC6HDAC8HDAC11HDAC3ALDH1A1 | |
| SCHEMBL22482879 | 0.72 | HDAC6 (0.56) | HDAC6HDAC8HDAC11HDAC3HDAC2 | |
| SCHEMBL22482725 | 0.71 | HDAC6 (1.00) | HDAC6HDAC8HDAC11HDAC3HDAC2 | |
| SCHEMBL19021370 | 0.71 | GSTP1 (0.48) | CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020194272-A1 | HALOGENATED PHENYLSULFONAMIDE HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS AND USES THEREOF AS SELECTIVE HDAC6 INHIBITORS | 2681603 ONTARIO INC. (CA) | 2020-10-01 | — | — | WO | disclosed |