Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22482999 | 0.94 | HDAC6 (0.48) | HDAC6HDAC8HDAC11CA12CA1 | |
| SCHEMBL22482998 | 0.90 | HDAC6 (0.55) | HDAC6HDAC8HDAC11CA12CA1 | |
| SCHEMBL24473203 | 0.82 | HDAC6 (0.58) | HDAC6HDAC8HDAC11HDAC3STAT3 | |
| SCHEMBL22483040 | 0.78 | HDAC6 (0.65) | HDAC6HDAC8HDAC11HDAC3 | |
| SCHEMBL19167335 | 0.74 | GSTP1 (0.48) | P2RX3 | |
| SCHEMBL24473205 | 0.73 | GSTP1 (0.42) | HDAC6HDAC8HDAC11CA12CA1 | |
| SCHEMBL22482879 | 0.73 | HDAC6 (0.56) | HDAC6HDAC8HDAC11CA12CA1 | |
| SCHEMBL19021370 | 0.72 | GSTP1 (0.48) | CA12CA1CA9P2RX3 | |
| SCHEMBL22483031 | 0.72 | HDAC6 (0.62) | HDAC6HDAC8HDAC11HDAC3P2RX3 | |
| SCHEMBL1350794 | 0.71 | GSTP1 (0.48) | CA12CA1CA9P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020194272-A1 | HALOGENATED PHENYLSULFONAMIDE HYDROXAMIC ACID COMPOUNDS, COMPOSITIONS AND USES THEREOF AS SELECTIVE HDAC6 INHIBITORS | 2681603 ONTARIO INC. (CA) | 2020-10-01 | — | — | WO | disclosed |