Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 4/20 | 0.42 |
| ▸ | ERN1 | O75460 | 6/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22466028 | 1.00 | TOP1 (0.43) | TOP1TOP2ATOP2BSNCAERN1 | |
| SCHEMBL22466002 | 1.00 | TOP1 (0.43) | TOP1TOP2ATOP2BSNCAERN1 | |
| SCHEMBL22466111 | 0.98 | TOP1 (0.41) | TOP1TOP2ATOP2BSNCAERN1 | |
| SCHEMBL22466015 | 0.98 | TOP1 (0.41) | TOP1TOP2ATOP2BSNCAERN1 | |
| SCHEMBL22466083 | 0.86 | HRH3 (0.44) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL29549366 | 0.84 | NPC1 (0.42) | TOP1TOP2ATOP2BSNCAERN1 | |
| SCHEMBL22465937 | 0.84 | NPC1 (0.42) | TOP1TOP2ATOP2BSNCAERN1 | |
| SCHEMBL22466035 | 0.83 | RAB9A (0.57) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29377773 | 0.83 | RAB9A (0.57) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29375281 | 0.82 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198368-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING | NEUROPORE THERAPIES, INC. (US) | 2020-10-01 | — | — | WO | disclosed |