Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 11/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22468358 | 1.00 | ATR (0.37) | ATRKDM4CKMT2APDE10ANPC1 | |
| SCHEMBL22468349 | 0.82 | KDM4C (0.40) | ATRKDM4CKMT2APDE10ANPC1 | |
| SCHEMBL29356162 | 0.82 | KDM4C (0.40) | ATRKDM4CKMT2APDE10ANPC1 | |
| SCHEMBL22488031 | 0.81 | ATR (0.37) | ATRKDM4CKMT2APDE10ANPC1 | |
| SCHEMBL22468364 | 0.72 | ATR (0.46) | ATRKMT2AKDM4EALDH1A1GAA | |
| SCHEMBL22488590 | 0.66 | NPSR1 (0.41) | KMT2APDE10AKDM4EALDH1A1GAA | |
| SCHEMBL22468414 | 0.66 | CYP2C19 (0.39) | KMT2AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL22468377 | 0.65 | KMT2A (0.43) | KMT2AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL22488554 | 0.65 | BRAF (0.43) | ATRKMT2AKDM4EALDH1A1GAA | |
| SCHEMBL29359114 | 0.65 | KMT2A (0.43) | KMT2AKDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| WO-2020198058-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2020-10-01 | — | — | WO | disclosed |