Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 11/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22468349 | 1.00 | KDM4C (0.40) | KDM4CL3MBTL1NPC1RAB9AATR | |
| SCHEMBL22468358 | 0.82 | ATR (0.37) | KDM4CNPC1RAB9AATRPDE10A | |
| SCHEMBL22488048 | 0.82 | ATR (0.37) | KDM4CNPC1RAB9AATRPDE10A | |
| SCHEMBL22488031 | 0.82 | ATR (0.37) | KDM4CNPC1RAB9AATRPDE10A | |
| SCHEMBL17594700 | 0.80 | KDM4C (0.45) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL22488550 | 0.78 | BRAF (0.48) | BRAF | |
| SCHEMBL29359192 | 0.77 | BRAF (0.43) | BRAF | |
| SCHEMBL22468354 | 0.77 | BRAF (0.43) | BRAF | |
| SCHEMBL22468414 | 0.74 | CYP2C19 (0.39) | KMT2AELOVL1BRAF | |
| SCHEMBL22468377 | 0.74 | KMT2A (0.43) | KMT2AELOVL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941922-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-01-26 | — | — | EP | disclosed |