Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | PPID | Q08752 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22489779 | 0.81 | CYP17A1 (0.46) | CCNCCDK8PRKCQKIF11GPBAR1 | |
| SCHEMBL11652269 | 0.80 | MEN1 (0.51) | CCNCCDK8CYP17A1LRRK2 | |
| SCHEMBL22489894 | 0.79 | CCNC (0.41) | CCNCCDK8GPBAR1 | |
| SCHEMBL22489835 | 0.78 | AAK1 (0.46) | PRKCQKIF11GPBAR1CYP17A1PTPN5 | |
| SCHEMBL17520239 | 0.77 | CCNC (0.48) | CCNCCDK8GPBAR1LRRK2 | |
| SCHEMBL20371450 | 0.77 | SLC22A12 (0.53) | CCNCCDK8GPBAR1CYP17A1KCNA5 | |
| SCHEMBL22489796 | 0.75 | TSHR (0.47) | GPBAR1GRIN1GRIN2B | |
| SCHEMBL22489858 | 0.75 | GPBAR1 (0.39) | CCNCCDK8GPBAR1 | |
| SCHEMBL14927060 | 0.75 | CCNC (0.51) | CCNCCDK8GPBAR1CYP17A1KCNA5 | |
| Bromide SCHEMBL29018736 | 0.74 | CCNC (0.50) | CCNCCDK8GPBAR1KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236055-B2 | Non-systemic TGR5 agonists | Venenum Biodesign, LLC (US) | 2022-02-01 | — | — | US | disclosed |
| US-20200308122-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | Venenum Biodesign, LLC (US) | 2020-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200308122-A1 | NOVEL NON-SYSTEMIC TGR5 AGONISTS | GPR119, SSTR5, FFAR3 | CCNC 4831/4885CDK8 4427/4885PRKCQ 2557/4885 |
| US-11236055-B2 | Non-systemic TGR5 agonists | SSTR5, GPR119, FFAR3 | CCNC 4830/4885CDK8 4479/4885PRKCQ 2688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.