Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CHKA | P35790 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22304232 | 0.78 | EGFR (0.36) | EGFRJAK3 | |
| SCHEMBL17538627 | 0.78 | CSNK1D (0.38) | CITIKBKBCHUKEGFRCSNK1D | |
| SCHEMBL30248822 | 0.76 | RET (0.40) | CITIKBKBCHUKEGFRCSNK1D | |
| SCHEMBL22524176 | 0.76 | RET (0.40) | CITIKBKBCHUKEGFRCSNK1D | |
| SCHEMBL22502463 | 0.75 | IKBKB (0.38) | CITIKBKBCHUKEGFRCSNK1D | |
| SCHEMBL29375488 | 0.75 | IKBKB (0.38) | CITIKBKBCHUKEGFRCSNK1D | |
| SCHEMBL17394757 | 0.75 | AURKA (0.36) | CITIKBKBCHUKEGFRCSNK1D | |
| SCHEMBL22490022 | 0.73 | KDM4E (0.44) | CITIKBKBCHUKCSNK1DMAPK14 | |
| SCHEMBL24453350 | 0.71 | EGFR (0.66) | EGFRCSF1R | |
| SCHEMBL22524279 | 0.71 | EGFR (0.66) | EGFRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198469-A1 | METHOD FOR TREATING EPIDERMAL GROWTH FACTOR RECEPTOR-DRIVEN CANCERS WITH PROTEIN KINASE C INHIBITORS IN COMBINATION WITH AN EGFR-TYROSINE KINASE INHIBITOR | IDEAYA BIOSCIENCES INC. (US) | 2020-10-01 | — | — | WO | disclosed |