Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | FES | P07332 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.51 |
| ▸ | FER | P16591 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31635966 | 0.85 | AURKA (0.49) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL8137957 | 0.84 | HTR2A (0.54) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL21919961 | 0.81 | JAK2 (0.51) | JAK2FLT1KDRFLT3NTRK3 | |
| SCHEMBL22864675 | 0.80 | PDPK1 (0.52) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL21618384 | 0.80 | AURKA (0.50) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL26389859 | 0.80 | DYRK1A (0.50) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL5335065 | 0.79 | MTNR1A (0.70) | MTNR1AMTNR1BCYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL25303627 | 0.78 | AURKA (0.49) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL21919959 | 0.78 | MTNR1A (0.43) | MTNR1AMTNR1BHTR2CCYP2D6NPC1 | |
| SCHEMBL1050599 | 0.78 | MTNR1A (0.43) | DYRK1APLK4AURKAJAK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596075-B1 | AZAINDOLES AS INHIBITORS OF HPK1 | HOFFMANN LA ROCHE (CH) | 2023-10-11 | — | — | EP | disclosed |
| WO-2020198053-A1 | 2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-6-YL)-4-METHYLBENZAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS RIPK2 INHIBITORS FOR TREATING E.G. AUTOIMMUNE DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-10-01 | — | — | WO | disclosed |