Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.32 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL150307 | 0.87 | — | — | |
| SCHEMBL2228169 | 0.84 | — | — | |
| SCHEMBL9116722 | 0.84 | — | — | |
| SCHEMBL6887978 | 0.84 | — | — | |
| SCHEMBL828913 | 0.84 | — | — | |
| SCHEMBL6728259 | 0.84 | — | — | |
| Nitric Acid SCHEMBL240753 | 0.75 | CA5A (0.35) | ALDH1A1MEN1KMT2A | |
| SCHEMBL14321614 | 0.70 | — | — | |
| SCHEMBL9764794 | 0.67 | — | — | |
| SCHEMBL3369413 | 0.66 | NOTUM (0.42) | ALDH1A1KMT2ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998292-B2 | Burn rate enhancement of basic copper nitrate-containing gas generant compositions | AUTOLIV ASP, INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20060096679-A1 | Burn rate enhancement of basic copper nitrate-containing gas generant compositions | AUTOLIV ASP, INC. | 2006-05-11 | — | — | US | disclosed |
| US-20050098246-A1 | Burn rate enhancement via metal aminotetrazole hydroxides | AUTOLIV ASP, INC. | 2005-05-12 | — | — | US | disclosed |