Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 6/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247100 | 1.00 | MAPK10 (0.37) | MAPK10MAPK8NPSR1CCR3RORC | |
| SCHEMBL2249160 | 0.89 | MAPK10 (0.40) | MAPK10MAPK8NPSR1CCR3RORC | |
| SCHEMBL2256236 | 0.89 | MAPK10 (0.40) | MAPK10MAPK8NPSR1CCR3RORC | |
| SCHEMBL2249812 | 0.86 | MAPK10 (0.38) | MAPK10MAPK8NPSR1CCR3RORC | |
| SCHEMBL2252813 | 0.86 | MAPK10 (0.38) | MAPK10MAPK8NPSR1CCR3RORC | |
| SCHEMBL2257433 | 0.84 | MAPK10 (0.40) | MAPK10MAPK8NPSR1CCR3RORC | |
| SCHEMBL2250623 | 0.84 | MAPK10 (0.40) | MAPK10MAPK8NPSR1CCR3RORC | |
| SCHEMBL5653714 | 0.83 | RORC (0.38) | MAPK10MAPK8NPSR1CCR3RORC | |
| SCHEMBL3200015 | 0.83 | RORC (0.40) | MAPK10MAPK8NPSR1CCR3RORC | |
| SCHEMBL3198421 | 0.83 | RORC (0.40) | MAPK10MAPK8NPSR1CCR3RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989455-B2 | Compounds, compositions and methods | CYTOKINETICS, INC. (US) | 2011-08-02 | — | — | US | claimed |
| US-7989455-B2 | Compounds, compositions and methods | CYTOKINETICS, INC. (US) | 2011-08-02 | — | — | US | disclosed |