SCHEMBL22492974

SCHEMBL22492974

CCc1cc(C=C2SC(=S)NC2=O)ccc1O

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MYC P01106 2/20 0.73
MAX P61244 2/20 0.73
DYRK1A Q13627 3/20 0.70
PIM1 P11309 3/20 0.70
PIM3 Q86V86 2/20 0.70
PIM2 Q9P1W9 2/20 0.70
DYRK2 Q92630 1/20 0.70
CISD1 Q9NZ45 2/20 0.68
GSK3B P49841 2/20 0.67
MAOA P21397 1/20 0.67
MAOB P27338 1/20 0.67
CDC7 O00311 1/20 0.67
PLK4 O00444 1/20 0.67
DAPK3 O43293 1/20 0.67
DYRK3 O43781 1/20 0.67
PRKD3 O94806 1/20 0.67
MAP4K4 O95819 1/20 0.67
PRKCG P05129 1/20 0.67
CDK1 P06493 1/20 0.67
RPS6KB1 P23443 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22492973 1.00 MYC (0.73) MYCMAXDYRK1APIM1PIM3
SCHEMBL29376987 1.00 MYC (0.73) MYCMAXDYRK1APIM1PIM3
SCHEMBL18095862 0.86 MYC (0.68) MYCMAXDYRK1APIM1PIM3
SCHEMBL18095865 0.86 MYC (0.68) MYCMAXDYRK1APIM1PIM3
SCHEMBL18103100 0.86 MYC (0.68) MYCMAXDYRK1APIM1PIM3
SCHEMBL15421744 0.85 MYC (1.00) MYCMAXDYRK1APIM1PIM3
SCHEMBL15421743 0.85 MYC (1.00) MYCMAXDYRK1APIM1PIM3
SCHEMBL15421742 0.85 MYC (1.00) MYCMAXDYRK1APIM1PIM3
SCHEMBL17397855 0.84 MYC (0.77) MYCMAXDYRK1APIM1PIM3
SCHEMBL17397854 0.84 MYC (0.77) MYCMAXDYRK1APIM1PIM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof PARIS SCIENCES ET LETTRES (FR) 2026-03-31 US disclosed
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES (FR) 2022-06-02 US disclosed
EP-3947355-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres (FR) 2022-02-09 EP disclosed
WO-2020201538-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF PARIS SCIENCES ET LETTRES – QUARTIER LATIN (FR) 2020-10-08 WO disclosed
EP-3719007-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF Paris Sciences et Lettres - Quartier Latin (FR) 2020-10-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220169682-A1 SPLIT PHOTOACTIVE YELLOW PROTEIN COMPLEMENTATION SYSTEM AND USES THEREOF BLVRB, IK, HBG2 MYC 1462/4885MAX 118/4885DYRK1A 75/4885
US-12590127-B2 Split photoactive yellow protein complementation system and uses thereof BLVRB, HBG2, Q6ZSR9 MYC 1156/4885MAX 81/4885DYRK1A 151/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.