Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 14/20 | 0.66 |
| ▸ | EGFR | P00533 | 18/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.64 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2249644 | 0.98 | EGFR (0.63) | ERBB2EGFRLCKERBB4AURKA | |
| SCHEMBL2250458 | 0.96 | EGFR (0.66) | ERBB2EGFRLCKERBB4AURKA | |
| SCHEMBL2250018 | 0.93 | EGFR (0.68) | ERBB2EGFRLCKABL1RAF1 | |
| SCHEMBL2255364 | 0.92 | EGFR (0.68) | ERBB2EGFRLCKAURKARPS6KB1 | |
| SCHEMBL2255170 | 0.91 | ERBB2 (0.67) | ERBB2EGFRLCKERBB4AURKA | |
| SCHEMBL2249394 | 0.91 | EGFR (0.73) | ERBB2EGFRLCKERBB4ABL1 | |
| SCHEMBL2251124 | 0.90 | EGFR (0.65) | ERBB2EGFRLCKABL1RAF1 | |
| SCHEMBL2249440 | 0.90 | ERBB2 (0.55) | ERBB2EGFRLCKERBB4ABL1 | |
| SCHEMBL15163194 | 0.89 | ERBB2 (0.66) | ERBB2EGFRLCKERBB4 | |
| SCHEMBL2252625 | 0.89 | EGFR (0.67) | ERBB2EGFRLCKERBB4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003658-B2 | Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-23 | — | — | US | claimed |
| US-8003658-B2 | Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-23 | — | — | US | disclosed |