Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2249347 | 0.98 | ERBB2 (0.66) | EGFRERBB2LCKERBB4KCNH2 | |
| SCHEMBL2250458 | 0.95 | EGFR (0.66) | EGFRERBB2LCKERBB4KCNH2 | |
| SCHEMBL2248785 | 0.91 | EGFR (0.72) | EGFRERBB2LCKERBB4 | |
| SCHEMBL2250018 | 0.91 | EGFR (0.68) | EGFRERBB2LCK | |
| SCHEMBL2255364 | 0.90 | EGFR (0.68) | EGFRERBB2LCKKCNH2AURKA | |
| SCHEMBL15162845 | 0.89 | ERBB2 (0.64) | EGFRERBB2LCKERBB4KCNH2 | |
| SCHEMBL2255170 | 0.89 | ERBB2 (0.67) | EGFRERBB2LCKERBB4KCNH2 | |
| SCHEMBL2249394 | 0.89 | EGFR (0.73) | EGFRERBB2LCKERBB4 | |
| SCHEMBL2251124 | 0.88 | EGFR (0.65) | EGFRERBB2LCK | |
| SCHEMBL2249440 | 0.88 | ERBB2 (0.55) | EGFRERBB2LCKERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003658-B2 | Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-23 | — | — | US | claimed |
| US-8003658-B2 | Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof | HANMI HOLDINGS CO., LTD. (KR) | 2011-08-23 | — | — | US | disclosed |